Rejuran is a regenerative skin treatment formulated around polynucleotides, short chains of purified DNA fragments derived from salmon. It is classified as a skin booster rather than a volume replacement treatment. The intent is not to fill a hollow or reshape a contour. The intent is to support the biological tissue that produces collagen, elastin and the extracellular matrix that gives skin its quality.
What polynucleotides are
Polynucleotides are fragments of nucleic acid material, biocompatible with human tissue and used in regenerative medicine in contexts well beyond aesthetics. The fragments used in Rejuran are highly purified and standardised to a clinical-grade specification. They are delivered into the dermis through a fine needle technique.
Once placed in the dermis, polynucleotides are understood to interact with fibroblasts, the cells responsible for producing collagen, elastin and the ground substance of the extracellular matrix. Laboratory and clinical literature describes signalling pathways associated with increased fibroblast activity, improved cellular hydration and a reduction in markers of oxidative stress.
What it is designed to support
Rejuran is typically considered for patients seeking improvements in skin quality rather than structural change. Hedged outcomes discussed at consultation may include:
- · Skin texture and surface smoothness.
- · Fine lines associated with dermal thinning.
- · Skin elasticity and overall firmness.
- · Periorbital skin quality, including the thin tissue under the eyes.
- · Hydration and the appearance of a healthier skin barrier.
Results develop gradually as the underlying tissue responds, not immediately as with a volume-led treatment.
What it is not
Rejuran is not a volume replacement treatment. It does not project tissue, restore a hollow or define a contour. It is not a neuromodulator, so it does not soften the muscle activity that creates dynamic expression lines. It is not a resurfacing device and does not ablate or remove tissue. Patients seeking those outcomes are better served by a different category of treatment, discussed at consultation.
Where it sits in a considered protocol
In a regenerative plan, Rejuran is typically delivered as a short course of sessions spaced several weeks apart, with maintenance considered later in the year. It is often sequenced alongside bio-remodelling, which addresses dermal hydration through a different mechanism, and medical skin needling, which focuses on surface texture. Where structural change is also part of the goal, energy-based work such as focused ultrasound may sit in the same plan, staged rather than stacked.
Suitability, risks and the consultation
Suitability is established in a one-on-one medical consultation. Aesthetic Haus is the aesthetic division of Plastic Surgery Queensland: consultations and treatments are delivered by trained Aesthetic Nurses under the clinical governance of FRACS Plastic and Reconstructive Surgeons. The consultation reviews medical history, current medications, skin history, allergies (including any history of salmon or fish allergy) and pregnancy or breastfeeding status.
Common transient responses can include localised swelling, small bruises at injection points, tenderness and short-lived firmness as the polynucleotide material integrates. Less common risks are discussed in detail at consultation. All cosmetic procedures carry risks and results vary.
This article is general information only and is not medical advice. A medical consultation is required before any cosmetic treatment.